Survey of Aminoglycoside Acetyl Transferase Genes in Multi-Drug Resistance Acinetobacter

Acinetobacter baumannii is a gram-negative, non fermenting cocobacills that its species are opportunistisic pathogens and cause nosocomial infections among patients in intensive care unit (ICUs).This bacteria cause various infections such as pneumonia, meningitis, endocarditis, and urinary tract [1]. Three decades ago, Acinetobacter baumannii infections treated with traditional antibiotics but today its show resistance to major classes of antibiotics including aminoglycosides, tetracyclines, fluroquinolones, carbapenms, cephalosporins, etc... At last year’s multidrug resistance (MDR) clinical isolates have shown global distribution [2]. Since Discovery and use of antibiotics, resistance to these agents has been observed. That has negative effect on the treatment of infectious disease [3]. Bacteria achieve their resistance to the antibiotics through three mechanisms: